科學(xué)研究：

研究方向：

主要從事高選擇性現(xiàn)代有機合成反應(yīng)設(shè)計，新型催化劑的設(shè)計與開發(fā)，新的反應(yīng)試劑的設(shè)計與開發(fā)。

承擔(dān)科研項目情況：

1． 上海市浦江人才計劃項目一項，2007.10-2009.9。

2． 上海市曙光人才項目一項，2008.1-2009.12。

3． 教育部新世紀(jì)人才項目一項，2009.1-2011.12。

4． 國家自然基金青年基金項目一項，2008.1-2010.12。

5． 國家自然基金面上基金項目一項，2009.1-2011.12。

6． 973項目一項，2009.1-2013.8，參與。

7． 上海市重點基礎(chǔ)研究項目一項，2008.9-2011.8，參與。

8． 第12屆霍英東基金基礎(chǔ)研究項目一項。

科研成果：

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發(fā)明專利：

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論文專著：

發(fā)表學(xué)術(shù)論文30余篇。

出版專著：

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發(fā)表英文論文：

2010年

1. Zuliang Chen? Junliang Zhang* An Unexpected Phosphine-Catalyzed Regio- and Diastereoselective [4+1] Annulation Reaction of Modified Allylic Compounds with Activated Enones. Chem. Ansia J. 2010? in press.

2. Wenbo Li? Yuying Li? Junliang Zhang* Gold-Catalyzed Domino Reactions Consisting of Regio- and Stereoselective 1?2-Alkyl Migration. Chem. Eur. J. 2010? 16? 6447-6450.

3. Yanqing Zhang? Feng Liu? Junliang Zhang* Catalytic Regioselective Control in the Diastereoselective 1?3-Dipolar Cycloaddition Reactions of 1-(1-Alkynyl)cyclopropyl Ketones with Nitrones. Chem. Eur. J. 2010? 16? 6146-6150.

4. Wanxiang Zhao? Junliang Zhang* Rhodium-catalyzed tandem nucleophilic addition/bicyclization of diyne-enones with alcohols: a modular entry to 2?3-fused bicyclic furans. Chem. Commun. 2010? 46? 4384-4386.

5. Tao Wang? Junliang Zhang* Synthesis of 2-acylfurans from 3-(1-alkynyl)-2-alken-1-ones via the oxidation of gold-carbene intermediates by H2O2. Dalton Trans. 2010? 39? 4270-4273.

6. Xiuzhao Yu? Bo Du? Kai Wang? Junliang Zhang* Highly Substituted 2?3-Dihydroisoxazoles by Et3N-Catalyzed Tandem Reaction of Electron-Deficient 1?3-Conjugated Enynes with Hydroxylamines. Org. Lett. 2010? 12? 1876-1879.

7. Hongyin Gao? Xiaoli Zhao? Yihua Yu? Junliang Zhang* Highly Substituted Furo[3?4-c]azepines by Gold(I)-Catalyzed Diastereoselective Tandem Double Heterocyclizations and 1?2-Alkyl Migration. Chem. Eur. J. 2010? 16? 456-459.

8. Yuanjing Xiao? Junliang Zhang* Tetrasubstituted allenes by Pd-0-catalyzed three-component tandem Michael addition/cross-coupling reaction. Chem. Commun. 2010? 46? 752-754.

2009年

9. Wenbo Li? Yuanjing Xiao? Junliang Zhang* Alkynyl Group as Activating Group: Base-Catalyzed Diastereoselective Domino Reactions of Electron-Deficient Enynes. Adv. Synth. Catal. 2009? 351? 3083-3088.

10. Zuliang Chen? Junliang Zhang* Highly Functionalized 4-Alkylidenebicyclo[3.1.0]hex-2-enes by Tandem Michael Addition and Annulation of Electron-Deficient Enynes. Chem. Asian J. 2009? 4? 1527-1529.

11. Renrong Liu? Junliang Zhang* Tetrasubstituted Furans by Pd-II-Catalyzed Three-Component Domino Reactions of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles and Vinyl Ketones or Acrolein. Chem. Eur. J. 2009? 15? 9303-9306.

12. Lu Liu? Junliang Zhang* Selectivity-Control in Lewis-acid Catalyzed Regiodivergent Tandem Cationic Cyclization/Ring Expansion Terminated by Pinacol Rearrangement. Angew. Chem. Int. Ed.? 2009? 48? 6093-6096.

13. Feng Liu? Yihua Yu? and Junliang Zhang* Highly Substituted Furo[3?4-d][1?2]oxazines: Gold-CatalyzedRegiospecific and Diastereoselective 1?3-Dipolar Cycloaddition of 2-(1-Alkynyl)-2-alken-1-ones with Nitrones. Angew. Chem. Int. Ed. 2009? 48? 5505 –5508.

14. Yuanjing Xiao? Junliang Zhang* Furans versus 4H-pyrans: catalyst-controlled regiodivergent tandem Michael addition–cyclization reaction of 2-(1-alkynyl)-2-alken-1-ones with 1?3-dicarbonyl compounds. Chem. Commun. 2009? 3954-3596.

15. Yanqing Zhang? Zuliang Chen? Yuanjing Xiao? Junliang Zhang* RhI-Catalyzed Regio- and Stereospecific Carbonylation of 1-(1-Alkynyl)cyclopropyl Ketones: A Modular Entry to Highly Substituted 5?6-Dihydrocyclopenta[c]furan-4-ones. Chem. Eur. J. 2009? 15? 5208-5211.

16. Yuanjing Xiao? Junliang Zhang* Palladium(II)-Catalyzed Domino Reaction of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles: Scope? Mechanism and Synthetic Application in the Synthesis of 3?4-Fused Bicyclic Tetrasubstituted Furans. Adv. Synth. Catal. 2009? 351? 617.

17. Hongyin Gao? Junliang Zhang* A Dramatic Substituent Effect in Silver(I)-Catalyzed Regioselective Cyclization of ortho-Alkynylaryl Aldehyde Oxime Derivatives Adv. Synth. Catal. 2009? 351? 85.

2008年

18. Liyan Fan? Wanxiang Zhao? Weihua Jiang? Junliang Zhang* One-Pot Synthesis of Fused Tricyclic Heterocycles with Quaternary Carbon Stereocenter by Sequential Pauson-Khand Reaction and Formal [3+3] Cycloaddition . Chem. Eur. J. 2008? 14? 9139-9142

19. Xiuzhao Yu? Hongjun Ren? Yuanjing Xiao? Junliang Zhang* Efficient Assembly of Allenes? 1?3-Dienes? and 4H-Pyrans by Catalytic Regioselective Nucleophilic Addition to Electron-Deficient 1?3-Conjugated Enynes . Chem. Eur. J. 2008? 14? 8481-8485

20. Yuanjing Xiao and Junliang Zhang* Tetrasubstituted Furans by a PdII-Catalyzed Three- Component Michael Addition/Cyclization/Cross-Coupling Reaction. Angew. Chem.? Int. Ed. 2008? 47? 1903-1906.

成立課題組以前的工作:

1. Shengming Ma* and Junliang Zhang. Pd0-catalyzed cyclization of aryl or alk-1-enyl halides with 1? 2-dienyl ketones: a general and efficient synthesis of polysubstituted furans. Chem. Commun. 2000. 117-118.

2.Shengming Ma? Lintao? Li? Qi Wei? Hexin? Xie? Guangwei Wang? Zhangjie? Shi and Junliang? Zhang. Hydrohalogenation reaction of electron-deficient allenes. Pur. & Appl. Chem. 2000? 72? 1739-1743.

3. Shengming Ma*? Hexin Xie? Guangwei Wang? Junliang Zhang and Zhangjie Shi. Hydrohalogenation Reaction of Substituted 1?2-allenic Carboxylic Acids? Esters? Amides? Nitriles? and Diphenyl Phosphine Oxides. Synthesis 2001? 713-730.

4. Shengming Ma* and Junliang Zhang. Efficient Synthesis of Benzocyclohexanes via Intramolecular Friedel-Crafts Reaction of Halogen Free 6-Acetoxy-4-alkenyl Arenes Tetrahedron Lett. 2002. 3435-3438.

5. Shengming Ma* and Junliang Zhang. TFA-Mediated Intramolecular Friedel-Crafts Reaction. An Efficient Metal and Halogen Free Route to Stereoselective Synthesis of Benzocycles. Tetrahedron 2003? 69? 6273-6283.

6. Shengming Ma*? Junliang Zhang andLianghua Lu. Pd0-Catalyzed Coupling Cyclization Reaction of Aryl or 1-Alkenyl Halides with 1? 2-Allenyl Ketones: Scope and Mechanism. An Efficient Assembly of 2? 3? 4-? 2? 3? 5-Tri- and 2? 3? 4? 5-Tetra-substituted Furans. Chem. Eur. J. 2003? 9? 2447-2456.

7. Shengming Ma*? Junliang Zhang? Yangjun Cai and Lianghua Lu. An X-(I-? Br-)-Triggered Ring-opening Coupling Reaction of Cyclopropenes with Organic Halides. J. Am. Chem. Soc. 2003? 125? 13954-13955.

8. Shengming Ma* and Junliang Zhang.2? 3? 4- or 2? 3? 5-Trisubstituted Furans: Catalyst-Controlled Highly Regioselectively Ring Opening Cycloisomeration Reaction of Cyclopropenyl Ketones. J. Am. Chem. Soc. 2003? 125? 12386-12387.

9. Shengming Ma* and Junliang Zhang. Tuning the Regioselectivity in Palladium(II)-Catalyzed Isomerization of Alkylidenecyclopropyl Ketones. A Dramatic Salt Effect. Angew. Chem. Int. Ed. 2003? 42? 184-187. (VIP).

10. Shengming Ma*?Lianghua Luand Junliang Zhang. Catalytic Regioselectivity Control in Ring Opening Cycloisomerization of Methylene- or Alkylidene- cyclopropyl Ketones. J. Am. Chem. Soc. 2004? 126? 9645-9660.

11. Shengming Ma*? Junliang Zhang? Lianghua Lu? Xin Jin? Yanjun Cai and Hairong Hou. NaI-Catalyzed Ring-Opening [1+2] cycloaddition Reaction of Cyclopropenes with imines. Highly Stereoselective Synthesis of cis-Vinylic Aziridines. Chem. Commun. 2005? 909-911.

12. Junliang Zhang? Cai-Guang Yang and Chuan He*. Gold(I)-Catalyzed Intra- and Intermolecular Hydroamination of Unactivated Olefins. J. Am. Chem. Soc. 2006? 128? 1798.

13. Junliang Zhang and Hans-Günther Schmalz*Gold(I)-Catalyzed Reaction of 1-(1-Alkynyl)-cyclopropyl Ketones with Nucleophiles: A Modular Entry to Highly Substituted Furans. Angew. Chem. Int. Ed. 2006? 45? 6704-6707.

14. Zigang Li? Junliang Zhang? Chad Brouwer? Cai-Guang Yang? Nicholas W. Reich? Chuan He* Br?nsted Acid Catalyzed Addition of Phenols? Carboxylic Acids and Tosylamides to Simple Olefins Org. Lett. 2006? 8? 4175-8.

15. Thomas Durek? Junliang Zhang? Chuan He and Stephen B. H. Kent* Synthesis of photoactive analogs of a cystine knot trypsin inhibitor protein. Org. Lett. 2007? 9? 5497-5500.

16. Uddhav Kumar Shigdel? Junliang Zhang and Chuan He* Diazirine-based DNA photo-cross- linking probes for the study of protein-DNA interactions. Angew. Chem.? Int. Ed. 2008? 47? 90-93.

發(fā)表中文論文：

資料更新中…… 

榮譽獎勵：

1． 2009年獲中國化學(xué)會青年化學(xué)家獎。

2． 入選上海市浦江人才計劃。

3． 入選曙光學(xué)者計劃。

4． 入選教育部新世紀(jì)人才計劃。

5． 獲上海市東方學(xué)者獎勵計劃資助。